Company Begins Advertising its Genetic Testing for Breast Cancer (dateline January 30, 2003)
In September 2002 Myriad Genetics became the first company to begin actively advertising their service of genetic testing. The company manufacturers a test that allows women to learn if they carry mutations of BRCA1 (breast cancer gene 1) or BRCA2 (breast cancer gene 2), which can significantly increase their risk of both breast cancer and ovarian cancer. Experts say this could be the beginning of increased advertising for healthcare services such as genetic testing as science becomes more advanced. They also worry that the advertising could mislead many women into thinking they need to undergo the controversial genetic testing.
BRCA gene mutations account for approximately 5% of breast cancer cases and approximately 9% of ovarian cancer cases. According to research by the Mayo Health Clinic, 20% of women who carry BRCA1 mutations will develop breast cancer by age 40, over 50% of women with BRCA1 mutations will get the disease by age 50, and over 80% of these women will be diagnosed with breast cancer by age 60. In addition, the lifetime ovarian cancer risk for women with BRCA1 or BRCA2 mutations is estimated to be between 17% and 44%.
This past September, Myriad began advertising in two markets: Atlanta and Denver, which represent 3% of the total eligible population. Myriad Genetics introduced their genetic test for BRCA gene mutations, the BRACAnalysis, in 1996. The cost of the test is $325 for a specific mutation and up to $2,760 for any of the approximately 2,000 identified BRCA mutations. Many insurance companies will cover a majority of the cost of the test, though few will cover the entire cost. Approximately 20,000 women have undergone BRCA gene testing since 1996.
Some experts, including Robin L. Bennett, a genetic counselor and president-elect of the National Society of Genetic Counselors acknowledge that the advertisements do suggest that women talk to their doctors about genetic testing prior to having the test. However, Bennett complains that the ads do not clearly explain the implications of testing positive for a BRCA gene mutation. Also, Bennett says that doctors are more likely than genetic counselors to advise genetic testing.
To test for BRCA1 or BRCA2 mutations, a small sample of blood is drawn, and the DNA is analyzed for BRCA defects. Both men and women may inherit and pass on BRCA1 or BRCA2 mutations. According to the Mayo Clinic, families that typically pass on BRCA defects have the following characteristics:
Genetic testing has been a controversial topic among medical professionals for several years now. Women with a strong family history of breast and/or ovarian cancer should weigh the advantages and disadvantages of genetic testing carefully before reaching a decision. Though most testing centers require genetic counseling prior to testing, all women considering genetic testing should discuss their situation with a counselor or physician.
Advantages to testing for BRCA mutations:
Disadvantages to testing for BRCA mutations: